○ Experience 

(2017-2018)  Stanford University, School of Medicine, 연구교수 

(2012-2017)  Stanford University, School of Medicine, Post-¬doctoral Researcher 

(2011-2012)  성균관대학교 에피지놈제어연구센터 선임연구원 

(2007-2011) 성균관대학교 약학대학 약학과 약학박사 (Biochemistry and Molecular Biology) 

(2005-2007) 성균관대학교 약학대학 약학과 약학석사 (Biochemistry and Molecular Biology) 

(2001-2005) 성균관대학교 약학대학 약학과 약학사 

○ Major Research Achievements  

- Paper 

1) Paik  DT,  Tian  L,  Lee  J,  Sayed  N,  Chen  IY,  Rhee  S,  Rhee  JW,  Kim  Y,  Wirka  RC,  Buikema  JW,  Wu   SM,  Red-­Horse  K, Quertermous  T,  Wu  JC.  Large-­Scale  Single-­Cell  RNA-­Seq  Reveals  Molecular   Signatures  of  Heterogeneous  Populations  of Human  Induced  Pluripotent  Stem  Cell-­Derived   Endothelial  Cells.  Circulation  Research.  (IF=15.211)  2018  Jul  9.  pii: CIRCRESAHA.118.312913. 

2) Lee  J,  Shao  NY,  Paik  DT,  Wu  H,  Guo  H,  Termglinchan  V,  Churko  JM,  Kim  Y,  Kitani  T,  Zhao  MT,   Zhang  Y,  Wilson KD, Karakikes  I,  Snyder  MP,  Wu  JC.  SETD7  Drives  Cardiac  Lineage  Commitment   through  Stage-­Specific  Transcriptional Activation.   Cell  Stem  Cell.   (IF=23.290)   2018  Mar   1;22(3):428-­444 

3) Zhao  M,  Shao  NY,  Hu  S,  Srinivasan  R,  Jahaniani  F,  Lee  J,  Snyder  M,  Wu,  J.  Cell  type-­specific   chromatin  signatures underline  regulatory  DNA  elements  in  human  induced  pluripotent  stem  cells   and  somatic  cells.  Circulation  Research. (IF=15.211)  2017;  121(11):1237-­1250. 

4) Churko  J,  Lee  J,  Ameen  M,  Gu  M,  Diecke  S,  Sallam  K,  Im  H,  Wang  G,  Gold  JD,  Salomonis  N,   Snyder  MP,  Wu  J. Transcriptomic  and  Epigenomic  Differences  in  Human  Induced  Pluripotent  Stem   Cells  Generated  from   Six   Reprogramming  Methods.   Nature  Biomedical  Engineering.   2017   October  3;  1(10):826-­837. 

5) Go  GY,  Lee  SJ,  Jo  A,  Seo  DW,  Kang  JS,  Kim  YK,  Kim  SK,  Kim  SN,  Lee  J,  Bea  GU.  Ginsenoside   Rg1  from  Panax ginseng  Enhances  Myoblast  Differentiation  and  Myotube  Growth.  Journal  of   Ginseng  Research.  (IF=4.053)  2017;  41(4):608-­614. 

6) Lee  S,  Serpooshan  V,  Tong  X,  Venkatraman  S,  Lee  M,  Lee  J,  Chirikian  O,  Wu  JC,  Wu  SM,  Yang  F.   Contractile  force generation  by  3D  hiPSC-­derived  cardiac  tissues  is  enhanced  by  rapid   establishment  of  cellular  interconnection  in  matrix with  muscle-­mimicking  stiffness.  Biomaterials.   (IF=8.806)  2017  Jul;131:111-­120. 

7) Gu  M,  Shao  NY,  Sa  S,  Li  D,  Termglinchan  V,  Ameen  M,  Karakikes  I,  Sosa  G,  Grubert  F,  Lee  J,  Cao   A,  Taylor  S,  Ma Y,  Zhao  Z,  Chappell  J,  Hamid  R,  Austin  ED,  Gold  JD,  Wu  J,  Snyder  MP,  Rabinovitch   M.  Patient-­Specific  iPSC-­Derived Endothelial  Cells  Uncover  Pathways  that  Protect  against   Pulmonary  Hypertension  in  BMPR2  Mutation  Carriers.  Cell  Stem Cell.  (IF=23.290)  2017  Apr   6;20(4):490-­504. 

8) Karakikes  I,  Termglinchan  V,  Cepeda  DA,  Lee  J,  Diecke  S,  Hendel  A,  Itzhaki  I,  Ameen  M,  Shrestha   R,  Wu  H,  Ma  N, Shao  NY,  Seeger  T,  Woo  NA,  Wilson  KD,  Matsa  E,  Porteus  MH,  Sebastiano  V,  Wu   JC.  A  Comprehensive  TALEN-­Based Knockout  Library  for  Generating  Human  Induced  Pluripotent   Stem  Cell-­Based  Models  for  Cardiovascular  Diseases. Circulation  Research.  (IF=15.211)  2017   Feb  28  pii:116.309948. 

9) Yi  SA,  Um  SH,  Lee  J,  Yoo  JH,  Bang  SY,  Park  EK,  Lee  MG,  Nam  KH,  Jeon  YJ,  Park  JW,  You  JS,   Lee  SJ,  Bae  GU, Rhie JW,  Kozma  SC,  Thomas  G,  Han  JW.  S6K1  Phosphorylation  of  H2B  Mediates   EZH2  Trimethylation  of  H3:  A Determinant of  Early  Adipogenesis.  Molecular  Cell.  (IF=14.248)  2016   May  5;62(3):443-­52. 

10) Lee  JC,  Jung  S,  Ebert  A,  Wu  H,  Diecke  S,  Kim  Y,  Yi  H,  Park  SH,  Ju  JH.  Generation  of  functional   cardiomyocytes  from the  synoviocytes  of  patients  with  rheumatoid  arthritis  via  induced  pluripotent   stem  cells.  Scientific  Report.  (IF=4.259) 2016  Sep  9;6:32669.   

11) Park EK*, Lee JC*, Park JW, Bang SY, Yi SA, Kim BK, Park JH, Kwon SH, You JS, Nam SW, Cho EJ, Han JW. Transcriptional Regulation of Cancer Stem Cell Marker CD133 by Tumor Suppresser p53. Cell Death and Disease. (IF=5.965) 2015 Nov 5;6:e1964. (*These authors contributed equally to this work) 

12) Wu H, Lee JC, Vincent L, Wang Q, Gu M, Lan F, Churko J, Sallam K, Matsa E, Sharma A, Gold J, Engler AJ, Xiang Y, Bers D, Wu J. Selective inhibition of phosphodiesterase subtypes rescues compromised β-adrenergic signaling in disease-specific human induced pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell. (IF=23.290) 2015 Jul 2;17(1):89-100 

- Project 

역분화과정의 분자생물학적 기전 연구 (한국연구재단) 

○ Research Interest 

• 자가면역질환 모델 시스템 확립 연구 

• 질환 특이적인 역분화 줄기세포 생성 

• 환자의 역분화 줄기세포를 이용한 다양한 질환 modeling 기술 개발 

• 역분화 줄기세포를 이용한 drug screening system 구축 

• 세포치료제 기반 바이오 의약품 개발 연구 

• 구조 기반 유전체 통합 조절 시스템 구축