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- Medicine(Molecular oncology & Tumor immunology)
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Lee, Chang-Woo
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- cwlee1234@skku.edu
- 031-299-6121
- http://biomed.skku.edu/cwlee
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의학관 716303호실
○ 주요 학력, 경력 (Experience) 2012-present Sungkyunkwan University School of Medicine (Professor) 2010-present Samsung Advanced Institute for Health Sciences and Technology (Professor) 2006-2012 Sungkyunkwan University School of Medicine (Associate Professor) 2002-2006 National Cancer Center (Senior Research Associate) 1998-2000 Harvard Medical School (Post-doctoral fellow) 1994-1998 University of Glasgow (UK) / National Institute for Medical Research (Ph.D.) ○ 연구분야(Research Field) ▪New Regulatory mechanism and Pathogenesis mechanism of tumor immunity, immune checkpoint and autoimmunity ▪ Development of therapeutic technology for blood cancer, lymphoma and autoimmune diseases using low molecular compounds and antibodies ▪ A new mechanism of disease development and treatment of molecular disease by Ssu72 (dual protein phosphatase) and a new type of Pellino1 (ubiquitin E3 ligase) ○ 주요 연구논문(Major Research Achievements) ▪ Pellino1 is a double-strand break responsive E3 ligase which is required for reversible ATM activation via NBS1 ubiquitination. Nature Communications 2018 in revision (IF 12.353) ▪ Peli1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Molecular Cell 2018, 7(70):920-935 (IF 14.248) ▪ The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation. Nature Communications 2018, In press (IF 12.353) ▪ Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase. Hepatology 2015, 63(2016): 247-259 (IF 14.079) ○ 연구협력 필요 분야(Research Interest) ▪ Organic synthesis and Drug design ▪ Screening using bioinformatics database ▪ Mass analysis and target detection using high-resolution equipment ○ 연구협력 가능 분야(Research Collaboration) ▪ Cell signaling mechanism analysis ▪ Genetically Modified Mouse Model Pinotyping ▪ Verification of candidate for treatment substance safety