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- Biological Sciences
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Lee, Sangho
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- sangholee@skku.edu
- 031-290-5913
- http://sangho.skku.edu
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제2과학관 32163
○ 주요 학력, 경력 (Experience) ▪ B.S., Chemistry, Seoul National University ▪ M.S., Biochemistry, Seoul National University ▪ Ph.D., Biochemistry and Molecular Biology, UCLA ▪ Postdoctoral Fellow, NIDDK/NIH ○ 연구분야(Research Field) ▪ Structual basis for ubiquitination of small GTPases and ubiquitin recognition ▪ Structural biology of plant hormone signaling pathway ▪ Antibody screening and engineering for therapeutics and diagnosis ○ 주요 연구논문(Major Research Achievements) ▪ Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and quanine nucleotide conversion. eLife 6:e29154 (2017) ▪ Modulation of ABA signaling by altering VxGΦL motif of PP2Cs in Oryza sativa. Mol. Plant 10(9):1190-1205 (2017) ▪ Molecular characterization of single-chain antibody variable fragments (scFv) specific to Pep27 from Streptococcus pneumoniae. Biochem. Biophys. Res. Commun. 501:718-723 (2018) ○ 연구협력 필요 분야(Research Interest) ▪ Validation of ubiquitin signaling in animal models ▪ Chemical modification of peptide- and chemical-based molecules for modulation of plant hormone signaling ▪ Application of antibodies in animal models and in incorporation into nanobio sensors/devices ○ 연구협력 가능 분야(Research Collaboration) ▪ Structural studies of proteins and protein complexes in signaling pathways ▪ Quantitative studies of protein interactions ▪ Antibody screening and engineering