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- Medicine
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Lee, Kyunghoon
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- 031-299-6070
- leekh@skku.edu
- http://biomed.skku.edu/leekh
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의학관 714313호
○ Experience 1996 Ph.D. College of Medicine, Seoul National University 1998 – Present : Assistant professor, Associate professor & Professor, Sungkyunkwan university School of medicine 2001 – 2003 : Visiting professor, Ohio State University, U.S.A. 1995 – 1997 : Assistant professor, Dankook university College of medicine ○ Major Research Achievements · Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. Sci Rep. 2016 · P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer. BMB Rep. 2015 · P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. Cell Death Dis. 2014 · S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade. J Cell Biol. 2012 ○ Publications · Ribosomal Protein S3, a New Substrate of Akt, Serves as a Signal Mediator between Neuronal Apoptosis and DNA Repair. J. Biological Chemistry (2010) 285(38): 29457–68. · Negative Regulation of p53 by the Long Isoform of ErbB3 Binding Protein Ebp1 in Brain Tumors. Cancer Res. (2010) 70(23):9730-41. · Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochemical research (2009) 34(5):942-51. · Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci U S A. (2008) 105(43):16584-9. · Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function. BMB Rep. (2008) 41(12):840-5. · Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability FEBS letters (2008) 582(7):1073-1080. · Cellular localization of the full-length isoform of thetype 2 corticotropin releasing factor receptor (CRF-R2α) in the postnatal mouse cerebellar cortex. J. Neuroscience research. (2007) 85(9):1996-2005. ○ Research Interest · Degenerative diseases of the nervous system · Regeneration of the nervous system · Stem cell therapy of the spinal cord injury