○ 주요 학력, 경력 (Experience)
▪ 1998 BS, Seoul National University
▪ 2003 MS, Seoul National University (Medicine, Cancer Research)
▪ 2005 PhD. University of Vienna (Chemistry, Proteomics)
▪ 2005-2006 Postdoctoral Researcher, Medical University of Vienna
▪ 2006-2012 Postdoctoral fellow, Johns Hopkins University
▪ 2012-2016 Assistant professor, Sungkyunkwan University School of Medicine, Molecular and Cell Biology (Pharmacology)
▪ 2018-2019 Visiting Assistant professor, Johns Hopkins University
▪ 2016-present Associate professor, Sungkyunkwan University School of Medicine, Molecular and Cell Biology (Pharmacology)
○ 연구분야(Research Field)
▪ Selective mechanism of dopaminergic neuronal death
▪ Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
▪ Relationship between neurodegeneration and liquid-liquid phase separation
▪ Functional studies of Protein Lipidation
○ 주요 연구논문(Major Research Achievements)
▪Shin JH, Dawson VL, Dawson TM. SnapShot: pathogenesis of Parkinson's disease. Cell(2009) 139(2):440.e1-2
▪Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troncoso JC, Dawson VL, Dawson TM. PARIS (ZNF746) Represses PGC-1α Contributing to Neurodegeneration in Parkinson's Disease. Cell (2011) 144(5):689-702
▪Kang H, Shin JH. Repression of rRNA transcription by PARIS contributes to Parkinson’s disease. Neurobiology of Dis. (2014) 73C:220-228.
▪Stevens DA, Lee Y, Kang HC, Lee BD, Lee YI, Bower A, Jiang H, Kang SU, Andrabi SA, Dawson V, Shin JH*, Dawson TM*. Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proc. Natl. Acad. Sci. USA. (2015) 112(37):11696-701 *Co-corresponding author
▪Lee YI, Kang H, Ha YW, Chang KY, Cho SC, Song SO, Kim H, Jo A, Khang R, Choi JY, Lee Y, Park SC, Shin JH. Diaminodiphenyl sulfone-induced parkin ameliorates age-dependent dopaminergic neuronal loss. Neurobiol. Aging (2016) 41:1-10
▪Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, DawsonVL, Shin JH*, Dawson TM*. PINK1 primes parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival. Cell Reports (2017) 18(4):918-932 *Co-corresponding author
▪Ham S, Lee YI, Jo M, Kim H, Kang H, Jo A, Lee GH, Mo YJ, Park SC, Lee YS, Shin JH*, Lee Y*. Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model. Sci Rep. (2017) 7(1):525 *Co-corresponding author
▪Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH. Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget (2017) 8(30):48603-48618
○ 연구협력 필요 분야(Research Interest)
▪ In vivtro imaging of protein phase separation
▪ Structure modeling of protein prenylation
▪ Bioinformatic analysis
○ 연구협력 가능 분야(Research Collaboration)
▪ Brain Stereotaxic Gene Delivery
▪ Proteome research based on mass spectrometry
▪ Brain cryo-section/Immuno fluorescence study
▪ in vitro protein prenylation